Microflora Restore 3 - Replenishes Healthy Bacteria in the Intestinal Track

Broad Spectrum Synbiotic (Prebiotic / Probiotic)

Microflora Restore III (tm) - 60 capsules

Code 710C - 60 Capsules
Serving Size: 1 Capsule
Servings Per Day: 1 / Per Container: 60
Two Months Supply - $49.00
Product Label

his is the third and latest version of Microflora Restore, which we introduced to the public in 2002. In 2017, we introduced Microflora Restore II -- a complete synbiotic and mineral formula, and now we are introducing Microflora Restore III, a more targeted probiotic product.

Microflora Restore III is a unique product with the following characteristics:

Superior growth medium -- Non-GMO, vegan, hypoallergenic.
Verified strains -- Third-party DNA verified to ensure identity.
Vital probiotic varieties
- Bacillus megaterium -- a variety that produces antioxidant carotenoids in the GI tract that are highly bioavailable. A B12 producer. Aspergillus antagonist.
- Bacillus pumilus -- is a natural producer of vitamin B2 which also produces its own antioxidant carotenoids.
- Bacillus subtilis -- an extraordinarily hardy strain that balances the gut microbiome. This strain is so robust and resistant to environmental stresses that it has been used to study the behavior of microorganisms in outer space. 1
- Bacillus clausii -- A European strain with unique healing properties. B. clausii has been shown to prevent recurrent respiratory infections in children. 2
- Bacillus coagulans -- Closely associated with its ability to treat diarrhea, B. coagulans is also effective in digestive problems, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and the treatment of H. pylori, among other conditions. 3
Resists environment stress factors: These spore-based strains are innately resistant to light, heat, stomach acid, and time -- thus giving them longer shelf-life. They have a high level of internal resiliency.
Allergen Free: Artificial fillers, corn, dairy, egg, gluten, GMO's, nuts and soy.
Prebiotic Support: This formula has prebiotic support, maintaining its "stand-alone" functions. It is also compatible with Microflora Accelera X (see below). These prebiotics contain natural-occurring food-based polyphenols and polysaccharides and include the following:
- Bladderwrack extract (Fucus vesiculosus, wild-harvested, certified organic)
- Humic Acid
- Larch arabinogalactan (Larix spp.)
- Nordic chaga (Inonotus obliquus, wild-harvested, certified organic)
- Red reishi extract (Ganoderma lucidum, fruiting body, certified organic)
- Wakeme extract (Undaria pinnatifida, sporophyll, certified organic)

Code 711C - 8.45 fl. oz. (250 ml.)
48 Servings (48 Day Supply) - $26.50
Take one tsp. (5 ml.) daily, mixed in
a small glass of water or juice
Product Label

icroflora Acceler-X is a stand-alone, "full-spectrum" prebiotic -- (see "Primer" article below). We created this product for those who simply want an "easy-to-take" prebiotic to support the body's existing intestinal microflora.

[ Active Ingredients: Purified Water, acacia gum (gum arabic) 4, agave inulin 5, galacto-oligosaccharides 6, guar gum 7. Minor ingredients and excipients: zinc sulfate, magnesium sulfate, ferrous sulfate, potassium sorbate, citric acid, and boric acid. ]

A Quick Primer On Prebiotics

Stated in its simplest terms, prebiotics are fermentable plant fibers that feed the good bacteria that is already in the lower gastrointestinal tract. 8 By doing this, prebiotics improve the good-to-bad ratio of bacteria in the gut. Plant fibers, as you find in Microflora Acceler-X, pass through the small intestines undigested, and, depending on the type, nourish bacteria at various locations throughout the colon, which itself has anywhere between 400-500 different species of bacteria and more than 7,000 strains. 9 Among the many benefits conferred by a full-spectrum prebiotic, like Microflora Acceler-X, are:

Better mental health
Better immune function
Improved vitamin and mineral production and absorption
Improved regularity
Improved bone density
More energy / less fatigue
Less inflammation
Less appetite, making it easier to lose weight
Positive effects against gastritis and leaky gut
Among many others . . .

We call "Acceler-X" a "full-spectrum" prebiotic, because it nourishes bacteria that thrive in the early stages of the colon (i.e. galacto-oligosaccharides: cecum to transverse colon), later stages of the colon (i.e. inulin: traverse to sigmoid), and intermediate stages (acacia and guar gums).

Prebiotic Foods: Although a well-designed prebiotic can have dramatic effects on improving intestinal flora, it also helps to include more "prebiotic" foods in the diet. About 5 grams of plant-based "prebiotic fiber" per day is recommended. These are listed below with the approximate percentage of prebiotic-containing fiber:

Raw chicory root (>64%)
Raw Jerusalem artichoke (>31%)
Raw dandelion greens (>24%)
Raw garlic (>17%)
Raw leeks (>11%)
Raw onion (>8%)
Cooked onion (>5%)
Raw asparagus (5%)
Raw wheat bran (5%)
Raw banana (1%)

Footnotes

See: Global Healing Center article on B. subtilis.
See: NIH review of B. clausii.
See: Web MD review of B. coagulans.
Gum arabic establishes prebiotic functionality in healthy human volunteers in a dose-dependent manner. (2008) It should be noted that this study determined an optimal dosage of 10 g/d, it did not determine the synergistic effects when combined with other prebiotics. See also: Acacia Gum is a Bifidogenic Dietary Fibre with High Digestive Tolerance in Healthy Humans (2009); among others.
Agave Inulin Supplementation Affects the Fecal Microbiota of Healthy Adults Participating in a Randomized, Double-Blind, Placebo-Controlled, Crossover Trial (2015); Inulin-type fructans of longer degree of polymerization exert more pronounced in vitro prebiotic effects (2006); Production of Fructooligosaccharides from Inulin by Endoinulinases and Their Prebiotic Potential (2010); among others.
Supplementation of Diet with Galacto-oligosaccharides Increases Bifidobacteria, but not Insulin Sensitivity, in Obese Prediabetic Individuals (2017); Prebiotic inulin-type fructans and galacto-oligosaccharides: definition, specificity, function, and application in gastrointestinal disorders (2017); among many others.
In vitro analysis of partially hydrolyzed guar gum fermentation on identified gut microbiota (2016); Prebiotic Effects and Fermentation Kinetics of Wheat Dextrin and Partially Hydrolyzed Guar Gum in an In Vitro Batch Fermentation System (2015); Consumption of partially hydrolysed guar gum stimulates Bifidobacteria and butyrate-producing bacteria in the human large intestine (2015); among others.
Relationship of prebiotics and food to intestinal microflora, European Journal of Nutrition, October 2002, Volume 41, p. i11-i16.
Charalampopoulos, Dimitris; Rastall, Robert A. (ed.); Prebiotics and Probiotics Science and Technology, Springer Reference, New York, 2009. ISBN: 978-0-387-79059-6. p. 10.

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User Instructions

Take one to two capsules, with or without food, or as recommended by your healthcare practitioner. Contains: No corn, dairy, gluten, GMO's, soy, tree nuts, wheat, or yeast. No artificial excipients, binders, fillers, flow agents, or stearates used.

Probiotic Review
& Studies

The links below provide a starting point for an exploration of current probiotic research and relevant nutraceutical self-education. They represent a tiny fraction of research in this area that is recently published or currently in progress.

General

Bacillus species are superior probiotic feed-additives for poultry (2016) -- Despite the focus here on poultry, vital inferences can be made since the antibiotics sited have the same effect on humans. Glyphosate-based herbicides (like Roundup ®) are exerting powerful antibiotic effects on people, in residuals that will persist years after consumption. One soil scientist expert I conferred with said that the problem is so severe, he sees a situation evolving where probiotics MUST be consumed simply to live a normal human life. (Thank you, Monsanto.)

Bacillus megaterium

Development of a two-step cultivation strategy for the production of vitamin B12 by Bacillus megaterium (2014),
Metabolic engineering of cobalamin (vitamin B12) production in Bacillus megaterium (2010)
Biocontrol Activity of Volatile-Producing Bacillus megaterium and Pseudomonas protegens Against Aspergillus and Penicillium spp. Predominant in Stored Rice Grains: Study II (2018) -- This study, among other things demonstrates the powerful anti-fungal activity of B. megaterium.
Identification and characterization of a novel antimicrobial peptide compound produced by Bacillus megaterium strain isolated from oral microflora. (2018)
Bacillus megaterium adapts to acid stress condition through a network of genes: Insight from a genome-wide transcriptome analysis. (2018)
Fusion expression and anti-Aspergillus flavus activity of a novel inhibitory protein DN-AflR. (Feb., 2019) -- The importance of this study is the way it demonstrates how the L-Asp-L-Asn (DN) from B. megaterium inhibits the growth of Aspergillus flavus. Although the Aspergillus genus contains hundreds of species, the results of this study suggest that B. megaterium has very broad anti-fungal properties -- something we have already known, but now we have a better understanding of the mechanism.
Diversity of bacterial endophytes in Panax ginseng and their protective effects against pathogens. (2018) -- Granted, this is a plant study involving endophytic bacteria within ginseng. Nonetheless, it further supports the powerful anti-fungal activity of B. megaterium (through PgBE40). The implications of the study's conclusion: namely, that B. megaterium strains (among others studied) should be used as biocontrol agents suggests broader human nutraceutical applications.
Orthologues of Bacillus subtilis spore crust proteins have a structural role in the Bacillus megaterium QM B1551 spore exosporium. (2018) -- This study shows the synergistic relationship between B. megaterium and B. subtilis, both important components of MR III.

Bacillus pumilus

Bacillus pumilus reveals a Remarkably High Resistance to Hydrogen Peroxide Provoked Oxidative Stress. (2014)
Characterization of Bacillus Probiotics Available for Human Use (2004) -- "The B. pumilus strain and one B. cereus strain (B. cereus var. vietnami) were found to produce a bacteriocin-like activity against other Bacillus species. The results that provided evidence of colonization, immunostimulation, and antimicrobial activity support the hypothesis that the organisms have a potential probiotic effect."

Bacillus subtilis

12 Proven & Potential Benefits of the Probiotic B. subtilis (2016) -- Good review article with links to reputable studies to support stated claims.
Novel insight on probiotic Bacillus subtilis: Mechanism of action and clinical applications (Journal of Current Research in Scientific Medicine, review article, 2016) -- "In recent times, there has been significant progress in scientific evaluation and studies on probiotic Bacillus subtilis, revealing possible mechanisms of action like antimicrobial effect by synthesis of antimicrobial substances, antidiarrheal effect, immunostimulatory effect, competitive exclusion of pathogens, prevention of intestinal inflammation, and normalization of intestinal flora. Numerous preclinical and clinical studies on B. subtilis have shown its promising efficacy in the treatment and prevention of diarrhea of various etiologies. B. subtilis is certified as generally recognized as safe by Food and Drug Administration and features in the European Food Safety Authority Qualified Presumption of Safety, hence suggesting as safe for human use. All of these beneficial attributes make B. subtilis the most attractive probiotic species for various clinical conditions."

Bacillus clausii

Bacillus clausii - The Probiotic of Choice in the Treatment of Diarrhoea -- (Review article with downloadable PDF, 2015). "In this paper, evidence for the efficacy of Bacillus clausii, a spore forming probiotic (viz clinical studies) in the treatment of diarrhoea, prevention of antibiotic associated diarrhoea and in the prevention of side effects associated with Helicobacter pylori is presented. Mechanism of action suggested is through inhibition of pathogens and immunomodulatory effects. Bacillus clausii is the probiotic of choice in the treatment of diarrhoea as it has the added advantage of being a spore forming probiotic. It is therefore stable at room temperature and resistant to low pH ensuring that it reaches the small intestines where it can colonize and exert its beneficial effects."

Bacillus coagulans

9 Proven Health Benefits of Bacillus coagulans (2016) -- Good review article with links to reputable studies to support stated claims.
Effect of oral administration of Bacillus coagulans B37 and Bacillus pumilus B9 strains on fecal coliforms, Lactobacillus and Bacillus spp. in rat animal model -- (Veterinary World, Research article, 2016) -- Conclusions: "This study revealed that oral administration of either B. coagulans B37 or B. pumilus B9 strains might be useful in reducing coliform counts accompanied by concurrent increase in lactobacilli counts in the intestinal flora in rats." Comment: Although this is a rat study, the implications of the effects of B. coagulans and B. pumilus (both in MR III) in improving intestinal flora are made clear.